Toxicological profiles - Zinc by Syracuse Research Corporation

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A number of factors limits the usefulness of this study, including the presence of several compounds in the smoke that may have carcinogenic potential, the use of only female animals, and the short duration of the exposure (20 weeks). 2 Oral exposure Zinc has been orally administered in a variety of forms, such as zinc chloride, zinc sulfate, zinc oxide, powdered zinc, and others. Some of these compounds, such as zinc sulfate, have been administered in both hydrated and anhydrous forms. Study authors often do not state definitely which form was used in a particular study.

The age- and sex-adjusted mortality rates were compared to state and national rates. The analysis determined that lung cancer mortality was elevated in the region but was not found to be associated with exposure to environmental levels of lead or zinc. Many confounding factors were not considered in the analysis, such as smoking, occupation, and duration of residence in the area in question. 7 mg zinc/m of a zinc oxide/hexachloroethane smoke mixture (which produces zinc chloride), 1 hour/day, 5 days/week, for 20 weeks had a statistically significant increase in the incidence of alveologenic carcinoma (30% versus 8% in control) thirteen months after the end of exposure (Marrs et al.

Although neither zinc nor the amino acid proline are readily absorbed in the colon, complexing of zinc with proline during an in vivo intestinal perfusion in rats resulted in increased zinc absorption. Acrodermatitis enteropathica is a metabolic disorder that results in the malabsorption of zinc. However, when patients afflicted with this disorder were treated with human milk, zinc absorption was enhanced (Lombeck et al. 1975). It was reported by Evans (1980) that patients with acrodermatitis enteropathica have an impaired tryptophan metabolic pathway.

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