Ciba Foundation Symposium 81 - Peptides of the Pars

Content:
Chapter 1 Chairman's advent (pages 1–2): G.M. Besser
Chapter 2 The Intermediate Lobe of the Pituitary Gland: creation and history (pages 3–12): Aaron B. Lerner
Chapter three constitution and Chemistry of the Peptide Hormones of the Intermediate Lobe (pages 13–31): Alex N. Eberle
Chapter four comparability of Rat Anterior and Intermediate Pituitary in Tissue tradition: Corticotropin (ACTH) and ??Endorphin (pages 32–54): Richard E. Mains and Betty A. Eipper
Chapter five Processing, Turnover and unencumber of Corticotropins, Endorphins and Melanotropin within the Toad Pituitary Intermediate Lobe (pages 55–78): Y. Peng Loh
Chapter 6 ??Endorphin?Related Peptides within the Pituitary Gland: Isolation, identity and Distribution (pages 79–100): D. G. Smyth, S. Zakarian, J. F. W. Deakin and D. E. Massey
Chapter 7 effective constitution and Cytochemistry of the Mammalian Pars Intermedia (pages 101–127): M. E. Stoeckel, G. Schmitt and A. Porte
Chapter eight Distribution, Subcellular Localization and id of Immunoreactive ??Melanotropin within the Pituitary Gland and mind (pages 128–140): I. C. Porter, F. J. H. Tilders, A. Barnea and C. R. Parker
Chapter nine Nature and keep an eye on of Peptide free up from the Pars Intermedia (pages 141–165): Sue Jackson, J. wish, F. Estivariz and P. J. Lowry
Chapter 10 organic function of the Pars Intermedia in reduce Vertebrates (pages 166–179): Bridget I. Baker
Chapter eleven The Pars Intermedia and the Fetal Pituitary?Adrenal Axis (pages 180–195): R.E. Silman, Cathy road, Diane Holland, T. Chard, J. Falconer and J. S. Robinson
Chapter 12 capabilities of ??Melanotropin and different Opiomelanocortin Peptides in Labour, Intrauterine progress and mind improvement (pages 196–223): D. F. Swaab and J. T. Martin
Chapter thirteen Pars Intermedia Peptides: reviews in grownup people (pages 224–243): Sally J. Ratter, Lorraine McLoughlin, Glenda Gillies, Vicky Clement?Jones, J. desire and Lesley H. Rees
Chapter 14 organic activities of Melanocyte?Stimulating Hormone (pages 244–262): Mac E. Hadley, Christopher B. Heward, Victor I. Hruby, Tomi ok. Sawyer and younger C. S. Yang
Chapter 15 ? ?Melanotropin and mind functionality (pages 263–276): Jan M. Van Ree, Bela Bohus, Katharina M. Csontos, Willem Hendrik Gispen, Henk M. Greven, Frans P. Nijkamp, Fred A. Opmeer, Guus (A.) A. De Rotte, Tjeerd B. Van Wimersma Greidanus, Albert Witter and David De Wed
Chapter sixteen Melanocyte?Stimulating Hormone and Adaptive Behaviour (pages 277–294): Tjeerd B. Van Wimersma Greidanus, Guus (A.) A. De Rotte, Anthony J. Thody and Alex N. Eberle
Chapter 17 Chairman's remaining feedback (pages 299–300): G.M. Besser

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Extra resources for Ciba Foundation Symposium 81 - Peptides of the Pars Intermedia

Example text

The one-dimensional interpretation of the function of the different peptide residues is a first approach to the understanding of the mechanism of action. Of course it is difficult to do such studies with very long peptides or with proteins having a defined tertiary structure. We must also be cautious in interpreting the results obtained with short peptides such as a-MSH. This peptide does not have a particular, isolated address sequence but, rather, two independent message sequences (Eberle & Schwyzer 1975), consisting in elements that trigger the receptor simultaneously when they bind to it.

This is the basis for the pleiotropic action of this class of peptides: different portions of a peptide can trigger different receptors (Eberle & Schwyzer 1976). only partially when the element1 responsible for the message sequence are obscured by additional structural elements. For instance, 0-LPH(41-9l), which contains the 0-MSH and the 0-endorphin sequence, exhibits no activity in the electrically stimulated guinea-pig ileum and shows only 5% of the activity of MSH (Lemaire et al 1978). The respective chainextensions of the parent peptide act as a CHEMmRY OF INTERMEDIATE LOBE PEPTIDES E l E2 E3 E4 E5 21 I E6 i E7 FIG.

0 60 80 Time (mid Prolonged Q P Free subunits C 0 40 80 120 160 200 240 Time (mid FIG. 6. Preparation and biological properties of a TMV-a-MSH conjugate (A. N. Eberle, V. M. Kriwaczek & R. Schwyzer, unpublished). See text for full explanation. In order to increase the ratio of hormone:carrier, Schwyzer proposed to use complexes between tobacco mosaic virus (TMV) and a-MSH, ACTH or enkephdin. TMV is a rod-shaped (18 x 300 nm) RNA virus with 2130 identical protein subunits (with 158 amino acid residues each) whose lysine68 can be specifically modified for the attachment of one peptide molecule per subunit.

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