By Rodriguez-Frade J.M., Mellado M., Martinez C.
The identify CCR2 refers to 2 then again spliced chemokine receptors: CCR2A and CCR2B. even supposing first pointed out because the particular, high-affinity receptor for MCP-1 found in monocytic cellphone strains, different che-mokines were proven to elicit responses via CCR2. CCR2 is expressed in monocytes, macrophages. T and В lymphocytes, usual killer (NK) cells, dendritic cells (DC), and in nonlymphoid cells and tissues. As one of many first chemokine receptors to be cloned and characterised, it's been studied widely. Its implication in numerous pathologies, its structure-activity courting, the signaling pathways activated, in addition to its law were analyzed intimately and it has served as a version for the examine of different chemokine receptors.
Read Online or Download CCR2 PDF
Similar nonfiction_1 books
Obinata G. , Dutta A. (eds. ) imaginative and prescient platforms. functions (I-Tech, 2007)(ISBN 9783902613011)(616s)_CsIp_-o
"Dilemmas of Internationalism" is a brand new political heritage of the Forties which charts and analyses the efforts of personal internationalists to outline US internationalism and advertise the institution of the United international locations. Internationalists was hoping that the USA could shake off the phobia of entangling alliances that had characterized the nation's historical past, changing isolationism and unilateralism with a brand new, concerned and multilateral method of overseas affairs.
- The Torsion Problem of Curved Beams
- The Surface-Tension at the Interface Between Two Liquids
- Chance Vought XF5U-1 Flying Pancake 1-32 ModelArt
- A note on nonlinear elliptic problems with singular potentials
- Measurement of the Spectroscopic Binary Star Mizar with the Interferometer
- Cutting Edge. Advanced Teacher's Resource Book
Extra resources for CCR2
39. Mula M, Trimble MR, Yuen A, et al. Psychiatric adverse events during levetiracetam therapy. Neurology 2003; 61(5):704–706. 40. Perucca E, Beghi E, Dulac O, et al. Assessing risk to benefit ratio in antiepileptic drug therapy. Epilepsy Res 2000; 41(2):107–139. 41. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003; 2(8):473–481. 42. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs.
31. Vajda FJ, Hitchcock A, Graham J, et al. Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. Eur J Neurol 2006; 13(6):645–654. 32. Tomson T, Battino D. Pharmacokinetics and therapeutic drug monitoring of newer antiepileptic drugs during pregnancy and the puerperium. Clin Pharmacokinet 2007; 46:209–219. 33. Perucca E, Berlowitz D, Birnbaum A, et al. Pharmacological and clinical aspects of antiepileptic drug use in the elderly. Epilepsy Res 2006; 68 (suppl 1):S49–S63.
Because of its potential hepatotoxic effects, valproate should be used cautiously or avoided in patients with hepatic disease, while carbamazepine should not be used in patients with preexisting dysfunction of the cardiac conduction system or cardiomyopathies (40). , valproate). Hence, AEDs are frequently involved in pharmacokinetic drug-drug interactions (41,42). In addition to changing the disposition of other drugs that patients may use, AEDs can be the substrate for interactions caused by other pharmaceutical agents.