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Additional resources for Bone Marrow-Derived Progenitors (Handbook of Experimental Pharmacology 180)
In rats, they reported on more than a 14-fold increase in peripheral blood MSCs after exposure to chronic hypoxia consistent with a role of MSCs in tissue repair (Rochefort et al. 2006). L. ) have tested various cytokines and cytokine combinations in a nonhuman primate model (manuscript in preparation). CFU-Fs were not observed in the peripheral blood of 8 baboons studied on two separate occasions in steady-state. We did not see any evidence for the mobilization of MSCs after G-CSF, pegylated G-CSF (supplied by Amgen), or G-CSF plus pegylated TPO/megakaryocyte growth and development factor (supplied by Kirin Brewery).
2004; Yu et al. 2004). Erices et al. found that 25% of 31 umbilical cord blood harvests contained cells with these characteristics and that there was a correlation with early gestational age and their presence. Bieback et al. found MSC-like cells in 63% of 59 umbilical cord blood units whereas Lee et al. isolated similar cells in all of 11 units using negative immunoselection and limiting dilution. Three other groups have reported difﬁculty in isolating MSCs from full-term cord blood samples (Gutierrez-Rodriguez et al.
Lévesque et al. including osteoblasts (Haynesworth et al. 1992b), chondrocytes (Johnstone et al. 1998), and adipocytes (Pittenger et al. 1999). These cells are isolated by an initial step of adherence to plastic, followed by a long period of cell culture to eliminate hematopoietic cells that spontaneously adhere to plastic such as granulocytes, monocytes, and macrophages. Due to controversy about whether these cells fulﬁll the criteria for stem cell activity, they have been variously termed marrow stromal cells (Pochampally et al.