Bone Marrow-Derived Progenitors (Handbook of Experimental by Katalin Kauser (Editor), Andreas Michael Zeiher (Editor)

By Katalin Kauser (Editor), Andreas Michael Zeiher (Editor)

Show description

Read Online or Download Bone Marrow-Derived Progenitors (Handbook of Experimental Pharmacology 180) PDF

Similar pharmacology books

Drug Use and Abuse (6th Edition)

DRUG USE AND ABUSE takes an interdisciplinary process in its assurance of present drug matters. It weaves mental, historic, cultural, social, organic, and scientific views -- emphasizing the concept a drug's results count not just on its homes, but in addition at the organic and mental features of its person.

Pharmaceutical Process Validation: An International

Stevens Institute of expertise, Hoboken, NJ. information suggestions to set up acceptable validation protocols and behavior procedure validation assignments, computer screen and try out particular production procedures for compliance with layout limits, and extra.

Development of Vaccines: From Discovery to Clinical Testing

Improvement of Vaccines: From Discovery to medical trying out outlines the severe steps, and analytical instruments and methods, had to take a vaccine from discovery via a winning scientific trial. Contributions from major specialists within the serious components of vaccine expression, purification, formula, pre-clinical trying out and regulatory submissions make this ebook an authoritative choice of matters, demanding situations and ideas for progressing a biologic drug formula from its early level of discovery into its ultimate medical checking out.

Additional resources for Bone Marrow-Derived Progenitors (Handbook of Experimental Pharmacology 180)

Example text

In rats, they reported on more than a 14-fold increase in peripheral blood MSCs after exposure to chronic hypoxia consistent with a role of MSCs in tissue repair (Rochefort et al. 2006). L. ) have tested various cytokines and cytokine combinations in a nonhuman primate model (manuscript in preparation). CFU-Fs were not observed in the peripheral blood of 8 baboons studied on two separate occasions in steady-state. We did not see any evidence for the mobilization of MSCs after G-CSF, pegylated G-CSF (supplied by Amgen), or G-CSF plus pegylated TPO/megakaryocyte growth and development factor (supplied by Kirin Brewery).

2004; Yu et al. 2004). Erices et al. found that 25% of 31 umbilical cord blood harvests contained cells with these characteristics and that there was a correlation with early gestational age and their presence. Bieback et al. found MSC-like cells in 63% of 59 umbilical cord blood units whereas Lee et al. isolated similar cells in all of 11 units using negative immunoselection and limiting dilution. Three other groups have reported difficulty in isolating MSCs from full-term cord blood samples (Gutierrez-Rodriguez et al.

Lévesque et al. including osteoblasts (Haynesworth et al. 1992b), chondrocytes (Johnstone et al. 1998), and adipocytes (Pittenger et al. 1999). These cells are isolated by an initial step of adherence to plastic, followed by a long period of cell culture to eliminate hematopoietic cells that spontaneously adhere to plastic such as granulocytes, monocytes, and macrophages. Due to controversy about whether these cells fulfill the criteria for stem cell activity, they have been variously termed marrow stromal cells (Pochampally et al.

Download PDF sample

Rated 4.62 of 5 – based on 41 votes