Biogenic Amines: Pharmacological, Neurochemical and by Tahira Farooqui, Akhlaq A. Farooqui

By Tahira Farooqui, Akhlaq A. Farooqui

Biogenic amines are clearly happening amines which are derived by means of enzymic decarboxylation of the traditional amino acids. They belong to a category of neurotransmitters together with catecholamines (dopamine, norepinephrine, and epinephrine), indolamine (serotonin), and imidazoleamine (histamine). Biogenic amines have nice pharmacological and physiological significance. the most goal of this ebook is to give readers with finished details on pharmacology, neurochemistry and molecular neurobiology of biogenic amine within the CNS of vertebrate and invertebrates in one quantity textual content. The e-book has been organised into chapters and sections to supply a greater circulate of knowledge. in addition, this specified quantity presents its readers with leading edge details on biogenic amines. it may be utilized by graduate scholars, postdoctoral fellows, researchers, and scientists who paintings on the pharmaceutical as a instruction manual, which describes all elements of biogenic amine metabolism.

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Life moves beyond a requirement for norepinephrine to the need for dopamine. Sophia Savage working in my lab administered L-Dopa daily by intraperitoneal injection to both male and female TH-null mice from the time of weaning until the mice were nearly a year old. These mutants were small throughout their lives. Before their dose of L-Dopa each day they were inactive and looked forlorn. The administration of L-Dopa by intraperitoneal injection caused nearly instant activity and frantic eating on the part of the TH-null mice.

1992;13:469-471. [37] Aguanno A, Lee MR, Marden CM, Rattray M, Gault A, Albert VR. Analysis of the neuronal promoter of the rat aromatic L-amino acid decarboxylase gene. Journal of Neurochemistry. 1995;65:1944-1954. [38] Dugast C, Weber MJ. NF-Y binding is required for transactivation of neuronal aromatic L-amino acid decarboxylase gene promoter by the POU-domain protein Brn-2. Brain Research Molecular Brain Research. 2001;89:58-70. [39] Schimmel JJ, Crews L, Roffler-Tarlov S, Chikaraishi DM. 5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors.

The observation that AAAD is also found in non-monoaminergic neurons in brain (AAAD+) [8,9], peripheral tissues [10] as well as in glial cells [11] supports the idea of additional, yet to be determined, roles for the enzyme. Dopamine and serotonin are necessary for normal nervous system function, and changes in their levels contribute to various pathologies. AAAD deficiency is a very rare autosomal recessive genetic disorder characterized by developmental delay, intellectual disability, abnormal movements and autonomic dysfunction [12].

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