By LaBlanc T. J., Pearl R.
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Extra info for A Further Note on the Age Index of a Population
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Because of its potential hepatotoxic effects, valproate should be used cautiously or avoided in patients with hepatic disease, while carbamazepine should not be used in patients with preexisting dysfunction of the cardiac conduction system or cardiomyopathies (40). , valproate). Hence, AEDs are frequently involved in pharmacokinetic drug-drug interactions (41,42). In addition to changing the disposition of other drugs that patients may use, AEDs can be the substrate for interactions caused by other pharmaceutical agents.