A Further Note on the Age Index of a Population by LaBlanc T. J., Pearl R.

By LaBlanc T. J., Pearl R.

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39. Mula M, Trimble MR, Yuen A, et al. Psychiatric adverse events during levetiracetam therapy. Neurology 2003; 61(5):704–706. 40. Perucca E, Beghi E, Dulac O, et al. Assessing risk to benefit ratio in antiepileptic drug therapy. Epilepsy Res 2000; 41(2):107–139. 41. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003; 2(8):473–481. 42. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs.

31. Vajda FJ, Hitchcock A, Graham J, et al. Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. Eur J Neurol 2006; 13(6):645–654. 32. Tomson T, Battino D. Pharmacokinetics and therapeutic drug monitoring of newer antiepileptic drugs during pregnancy and the puerperium. Clin Pharmacokinet 2007; 46:209–219. 33. Perucca E, Berlowitz D, Birnbaum A, et al. Pharmacological and clinical aspects of antiepileptic drug use in the elderly. Epilepsy Res 2006; 68 (suppl 1):S49–S63.

Because of its potential hepatotoxic effects, valproate should be used cautiously or avoided in patients with hepatic disease, while carbamazepine should not be used in patients with preexisting dysfunction of the cardiac conduction system or cardiomyopathies (40). , valproate). Hence, AEDs are frequently involved in pharmacokinetic drug-drug interactions (41,42). In addition to changing the disposition of other drugs that patients may use, AEDs can be the substrate for interactions caused by other pharmaceutical agents.

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